abstract：:Angelica keiskei (Miq.) Koidz. (Umbelliferae) has traditionally been used to treat dysuria, dyschezia, and dysgalactia as well as to restore vitality. Recently, the aerial parts of A. keiskei have been consumed as a health food. Various flavonoids, coumarins, phenolics, acetylenes, sesquiterpene, diterpene, and triter...

journal_title：Archives of pharmacal research

authors： Kil YS,Pham ST,Seo EK,Jafari M

更新日期：2017-06-01 00:00:00

abstract：:Urokinase-type plasminogen activator (uPA) has been validated as a predictive or prognostic biomarker protein, and mesupron is considered the first-in-class anticancer agent to inhibit uPA activity in human breast cancer. In the present study, we showed that the synergism between mesupron and auranofin, a thioredoxin ...

journal_title：Archives of pharmacal research

authors： Lee JE,Kwon YJ,Baek HS,Ye DJ,Cho E,Choi HK,Oh KS,Chun YJ

更新日期：2017-06-01 00:00:00

abstract：:Quercetin is a major component of the plant Glycyrrhiza uralensis, which is largely used as a traditional medicine in Asia. Quercetin has been reported to have several biological activities, which include anti-viral and anti-inflammatory effects. We explored the molecular mechanism linking anti-viral and anti-inflamma...

journal_title：Archives of pharmacal research

authors： Lee S,Lee HH,Shin YS,Kang H,Cho H

更新日期：2017-05-01 00:00:00

abstract：:Nucleoside analogues play an important role in antiviral, antibacterial and antineoplastic chemotherapy. Herein we report the synthesis, structural characterization and biological activity of some 4'-C -methyl- and -phenyl dioxolane-based nucleosides. In particular, α and β anomers of all natural nucleosides were obta...

journal_title：Archives of pharmacal research

authors： Franchini S,Battisti UM,Sorbi C,Tait A,Cornia A,Jeong LS,Lee SK,Song J,Loddo R,Madeddu S,Sanna G,Brasili L

更新日期：2017-05-01 00:00:00

abstract：:Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, is used for the treatment of rheumatoid arthritis and osteoarthritis. The predominant hepatic metabolism of celecoxib to celecoxib carboxylic acid (CCA) is mediated mainly by CYP2C9. We investigated the effects of the major CYP2C9 genetic variants in Asian popul...

journal_title：Archives of pharmacal research

authors： Kim SH,Kim DH,Byeon JY,Kim YH,Kim DH,Lim HJ,Lee CM,Whang SS,Choi CI,Bae JW,Lee YJ,Jang CG,Lee SY

更新日期：2017-03-01 00:00:00

abstract：:The proteins p150Sal2 (product of SALL2) and p53 share growth arrest and pro-apoptotic functions by independently inducing p21Cip1/Waf1 and BAX, and both proteins are targeted by the human papilloma virus E6 protein, leading to blockage of growth arrest in infected cells. Loss of both p53 and Sall2 in mice causes sign...

journal_title：Archives of pharmacal research

authors： Sung CK,Yim H

更新日期：2017-02-01 00:00:00

abstract：:A reliable analytical method based on high-performance liquid chromatography-ultraviolet detection was established for the determination of oleanonic acid (OA) content in Chios gum mastic (CGM). A simple method involving methanol extraction of CGM powder followed by basification and ether extraction was developed to i...

journal_title：Archives of pharmacal research

authors： Jin Y,Zhao J,Jeong KM,Yoo DE,Han SY,Choi SY,Ko DH,Kim HJ,Sung NH,Lee J

更新日期：2017-01-01 00:00:00

abstract：:Acute lung injury (ALI) is a respiratory failure disease and the major source of mortality in the critically ill patients. The main pathological changes involved in ALI include the excessive recruitment and activation of neutrophils by increased pro-inflammatory mediators. However, any specific therapy for ALI has not...

journal_title：Archives of pharmacal research

authors： Jang YJ,Back MJ,Fu Z,Lee JH,Won JH,Ha HC,Lee HK,Jang JM,Choi JM,Kim DK

更新日期：2016-12-01 00:00:00

abstract：:Cancer cells in the tumor microenvironment are affected by fluid shear stress generated by blood flow in the vascular microenvironment and interstitial flows in the tumor microenvironment. Thus, we investigated how fluidic shear stress affects cellular uptake as well as the endocytosis mechanism of nanoparticles using...

journal_title：Archives of pharmacal research

authors： Kang T,Park C,Lee BJ

更新日期：2016-12-01 00:00:00

abstract：:This study aimed to investigate the mechanism of cyanidin-3-glucoside (C3G) in synergy with atorvastatin, even when it is used in low concentrations. Human aortic smooth muscle cells (HASMCs) were used to verify the synergistic mechanism of atorvastatin and C3G against angiotensin II-induced proliferation and migratio...

journal_title：Archives of pharmacal research

authors： Pantan R,Tocharus J,Phatsara M,Suksamrarn A,Tocharus C

更新日期：2016-09-13 00:00:00

abstract：:Protein drugs have attracted considerable attention as therapeutic agents due to their diversity and biocompatibility. However, hydrophilic proteins possess difficulty in penetrating lipophilic cell membrane. Although protein transduction domains (PTDs) have shown effectiveness in protein delivery, the importance of s...

journal_title：Archives of pharmacal research

authors： Ul Ain Q,Lee JH,Woo YS,Kim YH

更新日期：2016-09-01 00:00:00

abstract：:Protease activated receptor 1 (PAR1) has been considered as a promising antiplatelet target to prevent thrombotic cardiovascular events in patients with prior myocardial infarction or peripheral arterial diseases. Previously, we found a series of octahydroindene analogues to have high potency on PAR1 and no significan...

journal_title：Archives of pharmacal research

authors： Park CM,Baek S,Kim S,Song JH,Lee S,Kim M

更新日期：2016-09-01 00:00:00

abstract：:Two new compounds (1-2), including a bisabolane-type sesquiterpenoid (1), one new diphenyl ether derivative (2), together with 23 known compounds (3-25), were isolated from the fruits of Phyllanthus emblica. Their structures were elucidated by detailed spectroscopic analysis. All the isolated compounds were screened f...

journal_title：Archives of pharmacal research

authors： Zhang Y,Zhao L,Guo X,Li C,Li H,Lou H,Ren D

更新日期：2016-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that modulates the transcription of a variety of genes to regulate important biological functions, including cell proliferation, differentiation, survival, angiogenesis, and immune response. Constitutive activation of STAT...

journal_title：Archives of pharmacal research

authors： Kim BH,Yi EH,Ye SK

更新日期：2016-08-01 00:00:00

abstract：:Two water-soluble polysaccharides termed MBBP-1 and MBBP-2 were isolated from the branches of the mulberry tree (Morus alba L.) using hot water extraction and purified on Anion-exchange DEAE52-cellulose and Sephadex G-100 column. MBBP-1 was shown to be composed of rhamnose, xylose, arabinose, mannose, glucose and gala...

journal_title：Archives of pharmacal research

authors： Qiu F,He TZ,Zhang YQ

更新日期：2016-07-01 00:00:00

abstract：:β-N-acetylglucosamine (β-AG) is a monosaccharide distributed widely in living organisms with various pivotal roles. The presence of particulates and impurities can affect the safety and efficacy of a product for its intended duration of use. Thus, the current study was carried out to identify and quantify the potentia...

journal_title：Archives of pharmacal research

authors： Kim YS,Lee SJ,Choi JY,Kim YH,Desta KT,Piao Z,Choi SL,Nam SJ,Kang KY,Abd El-Aty AM,Shin YC,Shin SC

更新日期：2016-07-01 00:00:00

abstract：:Phytochemical investigation of Ficus pandurata Hance (Moraceae) fruits has led to the isolation of two new triterpenoids, ficupanduratin A [1β-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (11) and ficupanduratin B [21α-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (17), along with 20 known compounds: α-amyrin acetate (1), ...

journal_title：Archives of pharmacal research

authors： Khedr AI,Ibrahim SR,Mohamed GA,Ahmed HE,Ahmad AS,Ramadan MA,El-Baky AE,Yamada K,Ross SA

更新日期：2016-07-01 00:00:00

abstract：:Paclitaxel (PTX)-loaded solid lipid nanoparticles without hydroxyl-β-cyclodextrin (PS) or with hydroxypropyl-β-cyclodextrin (PSC) were prepared by hot-melted sonication. Biocompatible and biodegradable stearic acid was used to produce the solid matrix. The stability of PS and PSC was assessed at different temperatures...

journal_title：Archives of pharmacal research

authors： Baek JS,Kim BS,Puri A,Kumar K,Cho CW

更新日期：2016-06-01 00:00:00

abstract：:Gemcitabine (2',2'-difluorodeoxycytidine, GCT) is an analog of deoxycytidine with cytotoxicity for breast cancer cells. However, because of its hepatotoxicity and other side effects, an efficient drug delivery system is needed for better therapeutic outcomes. A temperature-sensitive PEGylated immunoliposome (TSL) with...

journal_title：Archives of pharmacal research

authors： Shin DH,Koo MJ,Kim JS,Kim JS

更新日期：2016-03-01 00:00:00

abstract：:A new C-glycosylflavone, drymaritin E (6-C-(3-keto-β-digitoxopyranosyl)-4'-O-(β-D-glucopyranosyl)-7-methoxyl-5,4'-dihydroxylflavone) 1 was isolated from the oily upper phase (SU) of the MeOH extract from aerial parts of Drymaria cordata together with two known compounds (cassiaoccidentalin A 2 and anemonin 3) and an i...

journal_title：Archives of pharmacal research

authors： Nono RN,Nguelefack-Mbuyo EP,Nzowa LK,Ponou BK,Teponno RB,Nguelefack TB,Barboni L,Tapondjou LA,Park HJ

更新日期：2016-01-01 00:00:00

abstract：:Recently, the number of the cases in which weight loss products have been sold with illegal adulterants has increased, as awareness of the problems of obesity grows. In this study, we developed simultaneous analysis methods to rapidly and accurately identify ingredients illegally mixed with foods and dietary supplemen...

journal_title：Archives of pharmacal research

authors： Kim JY,Park HJ,Kim JW,Lee JH,Heo S,Yoon CY,Cho S

更新日期：2016-01-01 00:00:00

abstract：:Alkanolamines such as monoethanolamine (MEA), diethanolamine (DEA), and triethanolamine (TEA) are used as wetting agents in shampoos, lotions, creams, and other cosmetics. DEA is widely used to provide lather in shampoos and maintain a favorable consistency in lotions and creams. Although DEA is not harmful, it may re...

journal_title：Archives of pharmacal research

authors： Shin KO,Lee YM

更新日期：2016-01-01 00:00:00

abstract：:We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 × 2.1 mm, 5 µm). The mobile phase was 5 mM perchloric acid containing 5 % a...

journal_title：Archives of pharmacal research

authors： Gu MJ,Jeon JH,Oh MS,Hong SP

更新日期：2016-01-01 00:00:00

abstract：:The first asymmetric synthesis of (R,R)-clemastine (1) has been accomplished by the coupling of (R)-tertiary alcohol 2 and (R)-chloroethylpyrrolidine 3 via O-alkylation. (R)-Tertiary alcohol 2 was synthesized by stereoselective alkylation of chiral α-benzyloxy ketone with Grignard reagent via chelation-controlled 1,4-...

journal_title：Archives of pharmacal research

authors： Lee SY,Jung JW,Kim TH,Kim HD

更新日期：2015-12-01 00:00:00

abstract：:In this study, the enteric-coated delayed-release pellets of duloxetine hydrochloride (DLX) were formulated using a fluidized bed coater. Three separate layers, the drug layer, the barrier layer, and the enteric layer, were coated onto inert core pellets. Among the three formulations (F1-F3), the dissolution profiles ...

journal_title：Archives of pharmacal research

authors： Kim YI,Pradhan R,Paudel BK,Choi JY,Im HT,Kim JO

更新日期：2015-12-01 00:00:00

abstract：:This paper describes an investigation of novel RAGE inhibitors with improved drug-like properties. To identify the improved drug-like RAGE inhibitor, we designed and synthesized pyrimidine-2-carboxamide analogs based on our previous work. Several potent analogs with improved hydrophilicity were identified by evaluatio...

journal_title：Archives of pharmacal research

authors： Kim SH,Han YT

更新日期：2015-11-01 00:00:00

abstract：:A new isoprenylated flavonoid, 2S-5,7,2',4'-tetrahydroxy-3',5'-di-(γ,γ-dimethylallyl)flavanone, sanggenol Q (1), along with seven known isoprenylated flavonoids, sanggenol A (2), sanggenol L (3), kuwanon T (4), cyclomorusin (5), sanggenon F (6), sanggenol O (7), and sanggenon N (8), three known Diels-Alder type adduct...

journal_title：Archives of pharmacal research

authors： Jung JW,Ko WM,Park JH,Seo KH,Oh EJ,Lee DY,Lee DS,Kim YC,Lim DW,Han D,Baek NI

更新日期：2015-11-01 00:00:00

abstract：:Two lignan glycosides, acanthoside D (1) (=liriodendrin, (+)-syringaresinol di-O-β-D-glucopyranoside) and eleutheroside E (2) have been confused each other for so long time, and hard to be distinguished each other. Now, this two compounds need to be defined properly so that all the commercial mistakes and confusions s...

journal_title：Archives of pharmacal research

authors： Kil YS,Park JY,Kim Y,Nam SJ,Kim SJ,Kim YS,Seo EK

更新日期：2015-11-01 00:00:00

abstract：:Histone deacetylases (HDACs) regulate gene expression by creating the closed state of chromatin via histone hypoacetylation. Histone acetylation deregulation caused by aberrant expression of classical HDACs leads to imprecise gene regulation culminating in various diseases including cancer. Histone deacetylase inhibit...

journal_title：Archives of pharmacal research

authors： Ganai SA

更新日期：2015-10-19 00:00:00

abstract：:Megestrol acetate (MGA) belongs to the BCS class II drugs with low solubility and high permeability, and its oral absorption in conventional dosage form MGA microcrystal suspension (MGA MS) is very limited and greatly affected by food. In this study, MGA nanoemulsion (MGA NE) was formulated based on solubility, phase-...

journal_title：Archives of pharmacal research

authors： Li Y,Song CK,Kim MK,Lim H,Shen Q,Lee DH,Yang SG

更新日期：2015-10-01 00:00:00

abstract：:Drug discovery and development is vital to the well-being of mankind and sustainability of the pharmaceutical industry. Using chemical biology approaches to discover drug leads has become a widely accepted path partially because of the completion of the Human Genome Project. Chemical biology mainly solves biological p...

journal_title：Archives of pharmacal research

authors： Zhu Y,Xiao T,Lei S,Zhou F,Wang MW

更新日期：2015-09-01 00:00:00

abstract：:The global emergence of multi-drug resistant bacteria invokes an urgent and imperative necessity for the identification of novel antimicrobials. The general lack of success in progressing novel chemical entities from target-based drug screens have prompted calls for radical and innovative approaches for drug discovery...

journal_title：Archives of pharmacal research

authors： Ang ML,Murima P,Pethe K

更新日期：2015-09-01 00:00:00

abstract：:To establish a standard of quality control for Perillae Folium (Lamiaceae Family), four standard compounds including rosmarinic acid, elemicin, perillaldehyde, and dillapiole were evaluated by high-performance liquid chromatography (HPLC)/photodiode array (PDA). The four standards were analyzed with a Phenomenex Kinet...

journal_title：Archives of pharmacal research

authors： Zhao BT,Lee KR,Lee JH,Min BS,Son JK,Woo MH

更新日期：2015-08-01 00:00:00

abstract：:Angelica keiskei (Shin-sun cho) is an edible higher plant with the beneficial preventive effects on cancer, hypertension, and coronary heart disease. Two bioactive chalcones of Shin-sun cho, xanthoangelol (1) and 4-hydroxyderricin (2), were separated simultaneously by using high-speed counter-current chromatography wi...

journal_title：Archives of pharmacal research

authors： Kil YS,Nam JW,Lee J,Seo EK

更新日期：2015-08-01 00:00:00

abstract：:As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) gen...

journal_title：Archives of pharmacal research

authors： Choi JS,Haulader S,Karki S,Jung HJ,Kim HR,Jung HA

更新日期：2015-08-01 00:00:00

abstract：:Venlafaxine (VLX) could be pumped out of the brain by P-glycoprotein (P-gp). Moreover, the expression of P-gp distributed in blood-brain barrier could be significantly induced by VLX. Thus, P-gp could be considered as the nature barrier for delivering of VLX to the brain. The aim of this study was to investigate wheth...

journal_title：Archives of pharmacal research

authors： Zhou Y,Zhang G,Rao Z,Yang Y,Zhou Q,Qin H,Wei Y,Wu X

更新日期：2015-07-01 00:00:00

abstract：:The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in vitr...

journal_title：Archives of pharmacal research

authors： Lee JH,Ahn J,Kim JW,Lee SG,Kim HP

更新日期：2015-07-01 00:00:00

abstract：:2- and 4-methylimidazoles (2-MI and 4-MI) are undesired byproducts produced during the manufacture of caramel color used to darken food products such as carbonated beverages. The Office of Environmental Health Hazard Assessment in California listed 4-MI as carcinogen in January 2011 with a proposed no significant risk...

journal_title：Archives of pharmacal research

authors： Cho HH,Shin KO,Seo CH,Lee SH,Yoo HS,Yoon HR,Kim JW,Lee YM

更新日期：2015-07-01 00:00:00

abstract：:Two new anthraquinone dimers, melrubiellin A (1) and melrubiellin B (2), were isolated from the aerial part of Melandrium firmum Rohrbach, along with seven known compounds (3-9). The structures of these compounds were elucidated by spectral analyses, including 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. Co...

journal_title：Archives of pharmacal research

authors： Zhang CH,Yao DL,Li CS,Luo J,Jin M,Zheng MS,Lin ZH,Jin TF,Li G

更新日期：2015-06-01 00:00:00

abstract：:A method for screening nephroprotective compounds in cortex Moutan, a common traditional Chinese medicine (TCM) in treating diabetic nephropathy with renal mesangial cell extraction and ultra performance liquid chromatography technique was described in this paper. We hypothesize that the compounds which bind to cell m...

journal_title：Archives of pharmacal research

authors： Sun M,Huang L,Zhu J,Bu W,Sun J,Fang Z

更新日期：2015-06-01 00:00:00